21C Museum Hotel Lexington Exterior photo21C Museum Hotel Lexington Exterior photo21C Museum Hotel Lexington Exterior photo

21C MUSEUM HOTEL LEXINGTON

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From$251 /night
Check-in
10Jun
Check-out
11Jun
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

167 West Main Street, Lexington, 40507
-
Near Rupp Arena
Great
8.0
8.7
/10
4.4
4.2
/5

4-star art-infused boutique hotel in Lexington

Art and Museums

21c Museum Hotel Lexington boasts over 7,000 square feet of exhibition space featuring contemporary art. The property includes both solo and group exhibitions that reflect contemporary culture, with specially commissioned works by notable artists throughout the hotel. Guests regularly find installations like 'Totally in Love' by Pieke Bergman and 'Spectralline' by SOFTlab in prominent locations.

Dining Options

Lockbox, the on-site restaurant, offers a menu that highlights local ingredients while showcasing Kentucky's rich culinary heritage. Guests can enjoy breakfast, lunch, and dinner sourced from regional suppliers. The bar at Lockbox serves a variety of local beers, creative cocktails, and Kentucky Bourbons.

Accommodation Choices

The hotel provides a variety of room types, including the City Queen, Deluxe King, and the expansive 21c Suite with views of downtown Lexington. Each room is equipped with original artwork, custom-designed contemporary furnishings, and luxurious bedding from Malin + Goetz. Unique rooms, such as Nightwatch, offer immersive art environments that enhance the overall stay.

Event Facilities

21c Museum Hotel offers an array of event spaces, accommodating gatherings of up to 250 people. The main gallery is suitable for seated events of up to 112 guests, while five private galleries are available for smaller meetings. The hotel also provides state-of-the-art audiovisual capabilities for all corporate needs.

Location and Connectivity

Situated in downtown Lexington, the hotel lies at the intersection of southern charm and urban life. It serves as a strategic base for exploring local breweries, horse farms, and cultural landmarks within the city. Nearby attractions include the vibrant street art scene and various bourbon distilleries.

Highlights

Art: 7,000 square feet of exhibition space

Dining: Lockbox restaurant showcasing local cuisine

Rooms: City Queen, Deluxe King & 21c Suite options

Events: Main gallery with flexible seating capacities

“The art concept permeates the hotel, from public spaces to well-appointed rooms, creating a sophisticated atmosphere. Service is consistently attentive, and the downtown location proves very convenient for exploring local attractions. It's a genuinely stylish base in Lexington.”
Hotel logo
James DavidEditor-in-Chief at Uskentucky

Select your room type

21C Museum Hotel Lexington offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
  • City Queen Room
    2 persons
    22 sq. feet
    1 King-size bed
    Air conditioning
    Heating
  • Deluxe Queen Room
    2 persons
    33 sq. feet
    2 King Size Beds
    Air conditioning
    Heating
  • Deluxe King Room
    2 persons
    31 sq. feet
    1 King-size bed
    Air conditioning
    Heating
Show all rooms

Price and Room Availability Calendar

Check availability and prices for your dates now!
June 2026 - June 2027
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Check-in/ Check-out

Facilities

21C Museum Hotel Lexington offers amenities for your comfortable stay and unforgettable experiences
Facilities: Great
8.3/10Review score

General

  • No smoking on site
  • Free Wi-Fi in public areas
  • Safe deposit box
  • 24-hour reception
  • VIP check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • 24-hour security
  • Luggage storage
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access
  • Key access

Sports & Fitness

  • Fitness centre
  • Yoga class

Services

  • Paid shuttle service
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Special diet menus

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Children's menu

Room features

  • Air conditioning
  • Heating
  • Soundproofed rooms
  • Sitting area
  • Dressing area
  • Tea and coffee facilities
  • Dining table
  • Ironing facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • AM/FM alarm clock
Show more

Dining Onsite

At 21C Museum Hotel Lexington, dining transforms into a delightful exploration of local flavors and sustainable practices. Lockbox offers a contemporary American menu, while nearby options like La Cabana and Miguel's Pizza bring vibrant culinary experiences, perfect for indulging after a day of adventures.
21C Museum Hotel Lexington Restaurant photo
21C Museum Hotel Lexington Restaurant photo
21C Museum Hotel Lexington Restaurant photo

Lockbox

American, Local
Ambiance
A modern space that fuses artistry with comfort, Lockbox welcomes guests to unwind in a stylish yet relaxed setting.
Key Offerings
The culinary team can create a tailored catering menu to suit special occasions, with options accommodating vegetarian, vegan, gluten-free, and dairy-free diets. Highlights include innovative takes on classic dishes, beautifully presented.
Reservation
Recommended
Open for breakfast and dinner

La Cabana Mexican Restaurant

Mexican
Ambiance
A lively and colorful eatery, La Cabana embodies the spirit of Mexico, where guests are enveloped in a festive atmosphere ideal for groups and families.
Key Offerings
Famous for its hearty burritos and refreshing margaritas, this family-friendly café focuses on sustainability, sourcing ingredients locally for a more authentic taste.
Reservation
Not needed
Hours vary

Miguel's Pizza

Pizza
Ambiance
Renowned for its cozy, casual vibe, Miguel's Pizza is the perfect spot to gather with friends after a long day, offering a laid-back environment.
Key Offerings
A local favorite recognized for its delicious pizza slices, Miguel's has something for everyone looking to indulge in comfort food.
Reservation
Not needed
Hours vary

21C Museum Hotel Lexington Location

167 West Main Street, Lexington, 40507
Explore Lexington
Explore Lexington
  • Top Attractions
  • Activities
  • Dining
  • Entertainment
Rupp Arena
6 minutes' walk
Home to concerts and sports events, Rupp Arena is a vibrant venue with a storied history and seating for over 23,000.
University of Kentucky Art Museum
13 minutes' walk
Showcasing local and international art, this museum features changing exhibitions and a lovely setting for art lovers.
Transylvania University
10 minutes' walk
Established in 1780, notable for its historic campus and beautiful architecture, providing rich cultural insights.
Lexington Cemetery
4 minutes' drive
A peaceful space featuring stunning monuments and nature trails, perfect for leisurely strolls or reflection.
Horse Country Farm Tours
12 minutes' walk
Guided tours showcasing thoroughbred farms, providing a unique insight into Kentucky's equestrian culture.
The Arboretum
10 minutes' drive
A beautiful park with walking trails and gardens, ideal for relaxation or family picnics in a serene environment.
Bourbon on Rye
1 minute' walk
This casual spot offers Southern favorites and an extensive bourbon selection, perfect for a laid-back meal.
Corto Lima
3 minutes' walk
An upscale eatery serving fresh, farm-to-table Mexican cuisine, known for vibrant flavors and a cozy atmosphere.
School Sushi
2 minutes' walk
Offering creative sushi rolls in a trendy setting, great for a casual meal or takeout option for busy travelers.
Kentucky Theatre
5 minutes' walk
A historic cinema showing independent films and classic movies, offering an intimate setting for film enthusiasts.
WoodSongs Old-Time Radio Hour
10 minutes' walk
A weekly live music show featuring local and international artists, fostering a sense of community through music.
Getting around
  • City Centre
    Lexington 5 min  ·  1400 ft
  • Airports
    Blue Grass (LEX) 21 min  ·  8.5 mi
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
Wireless internet is available in public areas for free.
Children & extra beds
There are no extra beds provided in a room.  There are no cots provided in a room. 
Pets
Pets are allowed on request.
Number of floors:
15
Number of rooms:
88

Reviews and Ratings

Feedback about 21C Museum Hotel Lexington from previous guests about their experience.
Review score
Based on 439 verified reviews
8.2 /10
Great
75 %
Recommend
Cleanliness
8.5/10
Comfort
8.5/10
Facilities
8.3/10
Free WiFi
8.0/10
Location
8.9/10
Staff
8.6/10
Value for money
7.7/10
Pros
Historic building
Comfortable rooms
Art collection
Cons
Overpriced drinks
Room temperature issues
WiFi connectivity
Guest reviews
based on 300 reviews
8.0/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
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